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Lunch & Learn 11/08/2012
Lunch & Learn 11/08/2012


TRANSCRIPTIONAL BURST GENERATION VIA CLUSTERING
THE MECHANICS OF SNAKE LOCOMOTION
James Waters (Kim Lab)
Hamid Marvi (Hu Lab)


Certain gene transcription events occur in interesting temporal patterns, inadequately described by first-order kinetics, while still being governed by inherently stochastic processes. For instance, the production of messenger RNA in yeast cells is characterized by large bursts as opposed to individual uncorrelated events. We are investigating the co-localization or clustering of active sites as a mechanism to control this effect and we attempt to reproduce these bursts through numerical simulation of transcription factors diffusing in a model yeast nucleus. We present a detailed introduction to the development of our computational model, as well as preliminary results describing the effect of clustering sites on transcriptional bursting.
Snakes are one of the worlds most versatile locomotors, at ease slithering through rubble or ratcheting up vertical tree trunks. In our experimental study, we measured the frictional properties of several species of snakes as well as the kinematics of their locomotion. We conducted experiments to show that snakes’ scales can dig into the underlying surface to prevent sliding. We used this novel paradigm, the active control of scales to modify frictional properties, to build Scalybot 1 and 2, two snake-like robots with individually controlled sets of belly scales. In our supporting theoretical study, we developed a dynamic model of snakes’ locomotion to predict its speed and the forces it applies to its environment. We focus on common modes of a snake’s motion such as concertina, rectilinear, and sidewinding.
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Revision as of 17:19, 9 November 2012

This is the homepage of the Georgia Tech node of the international Physics of Living Systems (PoLS) student research network. The goal of this network is to foster interaction and collaboration among PoLS researchers within Georgia Tech and across institutes. Six core faculty members from the Schools of Biology, Physics, and Mechanical Engineering lead the Georgia Tech PoLS node.

The NSF Physics of Living Systems program sponsors research "exploring the most fundamental physical processes that living systems utilize to perform their functions in dynamic and diverse environments." The aim of PoLS research is to advance our understanding of the living world in a quantitative way, while also seeking to expand the intellectual range of physics paying through the lessons learned from the biological study.

At Georgia Tech PoLS research is carried out across a diversity of biological scales: single-molecule cellular organismal biophysics. Both theoretical and experiment biophysics research is conducted by core faculty members and affiliated faculty.

Signing-up for the email list

To receive email notification about upcoming GaTech-PoLS events and reminders about the weekly talks, sign-up for the email list. You can sign-up by simply sending a message

To: pols-request@lists.gatech.edu
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You should immediately receive a response telling you that you have joined.

Announcements

 
Lunch & Learn 11/08/2012

THE MECHANICS OF SNAKE LOCOMOTION
Hamid Marvi (Hu Lab)

Snakes are one of the worlds most versatile locomotors, at ease slithering through rubble or ratcheting up vertical tree trunks. In our experimental study, we measured the frictional properties of several species of snakes as well as the kinematics of their locomotion. We conducted experiments to show that snakes’ scales can dig into the underlying surface to prevent sliding. We used this novel paradigm, the active control of scales to modify frictional properties, to build Scalybot 1 and 2, two snake-like robots with individually controlled sets of belly scales. In our supporting theoretical study, we developed a dynamic model of snakes’ locomotion to predict its speed and the forces it applies to its environment. We focus on common modes of a snake’s motion such as concertina, rectilinear, and sidewinding.

Core faculty list

Core Faculty
PI Website Contact
Daniel I. Goldman http://crablab.gatech.edu daniel.goldman[at]physics.gatech.edu
Jennifer Curtis http://curtisresearch.gatech.edu/ jennifer.curtis[at]physics.gatech.edu
Kurt Wiesenfeld Department profile kurt.wiesenfeld[at] physics.gatech.edu
Joshua Weitz http://www.physics.gatech.edu/user/joshua-weitz jsweitz[at] gatech.edu
Harold Kim http://www.physics.gatech.edu/user/harold-kim harold.kim [at] physics.gatech.edu
David Hu http://www-old.me.gatech.edu/hu/ hu [at] me.gatech.edu

Support

This network is supported by the NSF Physics of Living Systems program within the physics division. The student research network is a part of the NSF Science across virtual institutes program to encourage interaction among researchers across many universities.