Seminars - Revision history

Cbalusek3: /* Georgia Tech Public Lecture Series */

2014-11-21T16:53:23Z

Georgia Tech Public Lecture Series

← Older revision		Revision as of 12:53, 21 November 2014
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	Joshua Weitz --- Georgia Inst. of Technology		Joshua Weitz --- Georgia Inst. of Technology

	'''Mathematical Models of the Ebola Virus Disease Outbreak in West Africa: Principles, Predictions, and Control'''		[http://www.physics.gatech.edu/seminars-colloquia/series/soft-condensed-matter-and-biophysics/joshua-weitz-20141125 '''Mathematical Models of the Ebola Virus Disease Outbreak in West Africa: Principles, Predictions, and Control''']

	Tue, Nov 25, 2014		*Tue, Nov 25, 2014
	3:00 pm in Klaus 1116		*3:00 pm in Klaus 1116

Cbalusek3: /* Georgia Tech Public Lecture Series */

2014-11-21T16:48:23Z

Georgia Tech Public Lecture Series

← Older revision		Revision as of 12:48, 21 November 2014
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	*Reception 4:30 pm		*Reception 4:30 pm
	*Lecture 5:00 pm in Student Center Ballroom		*Lecture 5:00 pm in Student Center Ballroom





	'''Soft and Condensed Matter Biophysics'''		'''Soft and Condensed Matter Biophysics'''
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	Tue, Nov 25, 2014		Tue, Nov 25, 2014
	3:00 pm in Klaus 1116		3:00 pm in Klaus 1116





	'''The Physics of Frankenstein'''		'''The Physics of Frankenstein'''

Cbalusek3 at 16:47, 21 November 2014

2014-11-21T16:47:59Z

← Older revision		Revision as of 12:47, 21 November 2014
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	==Georgia Tech Public Lecture Series==		==Georgia Tech Public Lecture Series==
			'''College of Computing Nobel Laureate Talk'''

			Michael Leavitt --- Stanford University

			'''Birth & Future of Multi-scale Modeling of Macromolecules'''

			*Mon, Nov 24, 2014
			*Reception 4:30 pm
			*Lecture 5:00 pm in Student Center Ballroom

			'''Soft and Condensed Matter Biophysics'''

			Joshua Weitz --- Georgia Inst. of Technology

			'''Mathematical Models of the Ebola Virus Disease Outbreak in West Africa: Principles, Predictions, and Control'''

			Tue, Nov 25, 2014
			3:00 pm in Klaus 1116

	'''The Physics of Frankenstein'''		'''The Physics of Frankenstein'''

Cbalusek3 at 18:00, 28 October 2014

2014-10-28T18:00:31Z

← Older revision		Revision as of 14:00, 28 October 2014
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			==Georgia Tech Public Lecture Series==

			'''The Physics of Frankenstein'''

			October 28, 2014 6:00 pm CULC 144

			Prof. Flavio Fenton

			School of Physics
			Georgia Inst. of Technology

	==Georgia Tech Applied Physiology==		==Georgia Tech Applied Physiology==

Cbalusek3 at 18:35, 19 August 2014

2014-08-19T18:35:41Z

← Older revision		Revision as of 14:35, 19 August 2014
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	~~==Georgia Tech Applied Physiology==~~

	~~Friday, March 29, 2013, 11:00 am - 12:00 pm~~

	~~Location: College of Computing, Room 101~~

	~~Integrating physiological, mathematical and 'musculo-robotic' tools to~~
	~~explore frog swimming and the design of vertebrate limbs~~

	~~Chris Richards, PhD~~


	~~Propulsion Physiology Lab~~
	~~Harvard University~~

	~~Abstract~~

	"A frog is a frog is a frog," wrote a famous poet. Comparative morphologists agreed, having observed stereotypical skeletal features making frogs unique among vertebrates. Meanwhile, motivated by separate
	interests, physiologists characterized intrinsic properties of frog muscle. Yet, despite our familiarity with frogs, the question of how they swim and jump as well as they do remains unanswered. How is this possible, given our rich knowledge of skeletal structure and muscle function? The unanswered question hints a broader issue: experimental biomechanics cannot directly test how muscle mechanics and skeletal morphology interact to determine locomotor performance. My research addresses this problem using aquatic frogs as a model. Integrating in vivo muscle techniques and hydrodynamic modeling, I found that aquatic frogs power swimming mainly from their ankle muscle (plantaris). In light of this, I developed a bio-robotic frog foot actuated by a living plantaris muscle in order to manipulate bio-robotic limb morphology, intrinsic muscle properties and motor control. My findings give new insight into how natural selection may adapt the morphological features of the skeleton to match the intrinsic properties of muscle (or vice versa). Specifically, I found that the contractile force and speed of the plantaris muscle are precisely 'tuned' to joint and webbed foot morphology such that frogs maximize muscle power
	produced as they swim. These findings may predict the limits of swimming speed across a broad range of size and timescales from aquatic insects to human rowing. Current and future work expands my 'musculo-robotics' tools to explore the musculoskeletal dynamics of walking, running and the evolution vertebrate limbs.

	==Georgia Tech Applied Physiology==		==Georgia Tech Applied Physiology==

Ashleyjeter at 18:50, 13 March 2013

2013-03-13T18:50:47Z

← Older revision		Revision as of 14:50, 13 March 2013
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			==Georgia Tech Applied Physiology==

			Friday, March 29, 2013, 11:00 am - 12:00 pm

			Location: College of Computing, Room 101

			Integrating physiological, mathematical and 'musculo-robotic' tools to
			explore frog swimming and the design of vertebrate limbs

			Chris Richards, PhD


			Propulsion Physiology Lab
			Harvard University

			Abstract

			"A frog is a frog is a frog," wrote a famous poet. Comparative morphologists agreed, having observed stereotypical skeletal features making frogs unique among vertebrates. Meanwhile, motivated by separate
			interests, physiologists characterized intrinsic properties of frog muscle. Yet, despite our familiarity with frogs, the question of how they swim and jump as well as they do remains unanswered. How is this possible, given our rich knowledge of skeletal structure and muscle function? The unanswered question hints a broader issue: experimental biomechanics cannot directly test how muscle mechanics and skeletal morphology interact to determine locomotor performance. My research addresses this problem using aquatic frogs as a model. Integrating in vivo muscle techniques and hydrodynamic modeling, I found that aquatic frogs power swimming mainly from their ankle muscle (plantaris). In light of this, I developed a bio-robotic frog foot actuated by a living plantaris muscle in order to manipulate bio-robotic limb morphology, intrinsic muscle properties and motor control. My findings give new insight into how natural selection may adapt the morphological features of the skeleton to match the intrinsic properties of muscle (or vice versa). Specifically, I found that the contractile force and speed of the plantaris muscle are precisely 'tuned' to joint and webbed foot morphology such that frogs maximize muscle power
			produced as they swim. These findings may predict the limits of swimming speed across a broad range of size and timescales from aquatic insects to human rowing. Current and future work expands my 'musculo-robotics' tools to explore the musculoskeletal dynamics of walking, running and the evolution vertebrate limbs.

	==Georgia Tech Applied Physiology==		==Georgia Tech Applied Physiology==

Ashleyjeter at 20:40, 8 February 2013

2013-02-08T20:40:34Z

← Older revision		Revision as of 16:40, 8 February 2013
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	Georgia Tech Applied Physiology		==Georgia Tech Applied Physiology==

	Brown-bag seminar series		Brown-bag seminar series

Ashleyjeter at 20:39, 8 February 2013

2013-02-08T20:39:19Z

← Older revision		Revision as of 16:39, 8 February 2013
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	Brown-bag seminar series		Brown-bag seminar series

			February 22, 2013 12:00 pm Room 1253, 555 14th St NW

	Age-related changes in human skeletal muscle from the myosin molecule to the whole muscle		Age-related changes in human skeletal muscle from the myosin molecule to the whole muscle
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	This seminar will focus on the effects of aging on human skeletal muscle and the use of a model system, Drosophila melanogaster (fruit fly), to help interpret the findings. Age-related skeletal muscle dysfunction and physical disability may be partially explained by alterations in the function of the myosin molecule. To test this possibility, skeletal muscle structure and function at the whole muscle, single fiber and molecular levels was measured in the knee extensors of young (21-35 years) and older (65-75 years) male and female volunteers matched for physical activity level. After adjusting for muscle size, older adults had similar isometric torque values compared to young, but had lower isokinetic power, primarily in females. At the molecular level, older adults, especially females, had slower myosin-actin cross-bridge kinetics (longer myosin attachment times and reduced rates of myosin force production), which may be explained by their reduced phosphorylation of the myosin regulatory light chain (RLC). The RLC phosphorylation decrease likely reduces cross-bridge formation by altering myosin’s orientation to actin, as found in Drosophila, an ideal system for examining muscle structure as measurements can be performed in living flies. Notably, cross-bridge kinetics in myosin heavy chain (MHC) IIA fibers correlated with whole muscle power output, indicating age-related changes at the molecular level decrease whole muscle dynamic performance in humans. A link between contractile and metabolic function was found as mitochondrial size was decreased in older adults, especially females, and was correlated to cross-bridge kinetics and whole muscle power output. These results are supported by Drosophila experiments that indicate mitochondria play a role in loss of flight ability with age. Collectively, our results show that age-related reductions in cross-bridge kinetics, most notable in females, represent a potential molecular mechanism underlying the development of physical disability with age. A possible future direction for this work is to evaluate rehabilitative interventions designed to increase cross-bridge kinetics, which may need to be sex-specific to address the unique cellular/molecular adaptations with age of males and females.		This seminar will focus on the effects of aging on human skeletal muscle and the use of a model system, Drosophila melanogaster (fruit fly), to help interpret the findings. Age-related skeletal muscle dysfunction and physical disability may be partially explained by alterations in the function of the myosin molecule. To test this possibility, skeletal muscle structure and function at the whole muscle, single fiber and molecular levels was measured in the knee extensors of young (21-35 years) and older (65-75 years) male and female volunteers matched for physical activity level. After adjusting for muscle size, older adults had similar isometric torque values compared to young, but had lower isokinetic power, primarily in females. At the molecular level, older adults, especially females, had slower myosin-actin cross-bridge kinetics (longer myosin attachment times and reduced rates of myosin force production), which may be explained by their reduced phosphorylation of the myosin regulatory light chain (RLC). The RLC phosphorylation decrease likely reduces cross-bridge formation by altering myosin’s orientation to actin, as found in Drosophila, an ideal system for examining muscle structure as measurements can be performed in living flies. Notably, cross-bridge kinetics in myosin heavy chain (MHC) IIA fibers correlated with whole muscle power output, indicating age-related changes at the molecular level decrease whole muscle dynamic performance in humans. A link between contractile and metabolic function was found as mitochondrial size was decreased in older adults, especially females, and was correlated to cross-bridge kinetics and whole muscle power output. These results are supported by Drosophila experiments that indicate mitochondria play a role in loss of flight ability with age. Collectively, our results show that age-related reductions in cross-bridge kinetics, most notable in females, represent a potential molecular mechanism underlying the development of physical disability with age. A possible future direction for this work is to evaluate rehabilitative interventions designed to increase cross-bridge kinetics, which may need to be sex-specific to address the unique cellular/molecular adaptations with age of males and females.

	~~February 22, 2013 12:00 pm Room 1253, 555 14th St NW~~

Ashleyjeter at 20:38, 8 February 2013

2013-02-08T20:38:42Z

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	February 22, 2013 12:00 pm Room 1253, 555 14th St NW		February 22, 2013 12:00 pm Room 1253, 555 14th St NW

	~~[[File:Example.jpg]]~~

Ashleyjeter at 20:37, 8 February 2013

2013-02-08T20:37:33Z

← Older revision		Revision as of 16:37, 8 February 2013
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	February 22, 2013 12:00 pm Room 1253, 555 14th St NW		February 22, 2013 12:00 pm Room 1253, 555 14th St NW

			[[File:Example.jpg]]